Chicken Bubble Biscuit Bake Casserole

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Golden, gooey, and packed with flavor, this Chicken Bubble Biscuit Bake Casserole is your ultimate weeknight comfort dish. Think tender chunks of chicken, creamy sauce, fluffy biscuits, and melty cheese all baked into one crave-worthy casserole. Topped with crispy bacon and a sprinkle of herbs, it’s the kind of dinner that vanishes fast and leaves everyone asking for seconds.

Whether you’re feeding a hungry family or just want something hearty and soul-warming, this casserole brings the magic. It combines everyday ingredients with a nostalgic twist that reminds you of grandma’s kitchen, but with a modern shortcut or two. Best of all? It’s incredibly easy to throw together on a busy evening.

What Kind of Biscuits Should I Use?

Refrigerated biscuit dough is the shortcut hero here. Opt for flaky-style biscuits if you love a layered bite, or homestyle for that classic Southern flavor. Either works well, but make sure you quarter them before baking so they bubble up nicely with the creamy base.

Ingredients for the Chicken Bubble Biscuit Bake Casserole

• Chicken: Cooked and shredded chicken breast or rotisserie chicken adds hearty protein and texture.
• Refrigerated Biscuits: These form the “bubble” texture. When baked, they puff and soak up the sauce.
• Cream of Chicken Soup: This brings creamy richness and blends the flavors together.
• Sour Cream: Adds tanginess and extra creaminess to the sauce.
• Shredded Cheddar Cheese: Melts into gooey goodness and gives that golden top.
• Crispy Bacon Bits: For a smoky crunch and irresistible topping.
• Garlic Powder & Onion Powder: Boost the savory profile of the dish.
• Chopped Parsley: For a fresh finish.

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How To Make the Chicken Bubble Biscuit Bake Casserole

Step 1: Prep the Oven and Pan

Preheat your oven to 350°F. Lightly grease a 9×13-inch baking dish so nothing sticks.

Step 2: Mix the Sauce

In a large bowl, whisk together cream of chicken soup, sour cream, garlic powder, and onion powder until smooth. Fold in the shredded chicken and half of the shredded cheddar cheese.

Step 3: Add Biscuits

Cut each biscuit into quarters and gently stir them into the chicken mixture until well coated. Spread this mixture into your prepared baking dish.

Step 4: Top and Bake

Sprinkle the remaining cheddar cheese over the top. Bake uncovered for 25-30 minutes or until the biscuits are cooked through and golden on top.

Step 5: Garnish and Serve

Remove from the oven and top with crispy bacon bits and fresh chopped parsley. Serve warm and watch it disappear!

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Serving and Storing Chicken Bubble Biscuit Bake Casserole

This dish is best served straight from the oven while the biscuits are warm and fluffy. Leftovers can be stored in an airtight container in the fridge for up to 3 days. Reheat in the oven or microwave, though the oven will help preserve the texture better.

What to Serve With Chicken Bubble Biscuit Bake Casserole?

Green Beans with Garlic Butter

A crisp and garlicky side helps balance the richness of the casserole.

Classic Caesar Salad

The crunch of romaine and the zingy dressing adds contrast to the creamy base.

Roasted Rosemary Sweet Potatoes

Sweet and savory, these make a cozy, nutrient-packed pairing. Try this recipe: Roasted Rosemary Sweet Potatoes

Southern Deviled Eggs

A nostalgic touch that complements the homey vibe. See how to make them here: Southern Deviled Eggs

Easy Cheesy Scalloped Potatoes

When you’re in the mood for a full-on comfort meal. Double the cheese, double the love: Easy Cheesy Scalloped Potatoes

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Want More Casserole Ideas?

If you loved this creamy, bubbling bake, here are more must-try casseroles that bring the same heartwarming energy:

• Hashbrown Chicken Casserole for a potato-packed twist.
• Slow Cooker Chicken and Dumplings if you want comfort that cooks itself.
• Creamy Parmesan Italian Sausage Soup for spoonfuls of cozy.
• Runza Casserole to try something uniquely Midwestern.
• Chicken Crescent Roll Casserole for buttery layers with a creamy center.

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Save This Pin For Later

Save this delicious idea to your favorite Pinterest board so it’s easy to find when you’re ready to whip it up again.

Tried it with a twist? Maybe a sprinkle of ranch seasoning or chopped jalapeños? I’d love to hear how it turned out—drop your tips or questions in the comments below.

Need more inspiration? Explore my daily kitchen creations on Savor Queen on Pinterest. Your next favorite might be waiting there.

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