Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

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There’s something irresistibly satisfying about a plate of creamy Cajun chicken fettuccine. It’s that perfect harmony of bold spice, velvety cheese, and tender pasta that makes each bite taste like comfort with a kick. This recipe is designed to capture everything you crave in a single dish—a cozy, creamy pasta paired with sizzling Cajun-spiced chicken and a luscious garlic mozzarella sauce that melts into every swirl of fettuccine.

Whether you’re prepping for a weeknight dinner or impressing guests at your next gathering, this dish comes together easily but delivers a gourmet-level punch. The garlic and Cajun seasoning fuse seamlessly into the mozzarella-laced cream sauce, creating a rich backdrop for juicy chicken slices. It’s indulgent, flavorful, and downright addictive.

What Kind of Fettuccine Should I Use?

While traditional fettuccine noodles made from semolina flour are a classic choice for this dish, you can also opt for fresh pasta if you’re aiming for extra tenderness and richness. Whole wheat fettuccine works beautifully too, adding a nutty undertone that complements the cream sauce. Avoid angel hair or thinner pasta, as they may not hold the thick sauce as effectively.

Ingredients for the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

• Fettuccine Pasta – The heart of the dish. Its thick ribbons hold onto the creamy sauce perfectly.
• Chicken Breasts – Sliced thin and seasoned generously with Cajun spice for that spicy, smoky bite.
• Cajun Seasoning – Brings heat, depth, and a bold Southern flair.
• Garlic – Infuses the sauce with savory aroma and flavor.
• Butter – Adds richness and helps toast the garlic.
• All-Purpose Flour – Used to thicken the base of the cheese sauce.
• Whole Milk – Creates a creamy, luscious texture.
• Mozzarella Cheese – The star of the sauce—melty, stretchy, and wonderfully mild.
• Salt & Black Pepper – Enhances all the flavors.
• Parsley (Optional) – For a fresh, herby finish.

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How To Make the Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

Step 1: Prep the Chicken

Season your sliced chicken breasts generously with Cajun seasoning. Heat a skillet over medium-high heat with a bit of olive oil and sear the chicken on both sides until cooked through and lightly charred. Remove and set aside.

Step 2: Cook the Pasta

Bring a large pot of salted water to a boil and cook the fettuccine according to package instructions until al dente. Drain and set aside, reserving a bit of pasta water.

Step 3: Make the Garlic Roux Base

In a large pan, melt the butter over medium heat. Add minced garlic and cook until fragrant. Sprinkle in the flour and whisk constantly to create a roux, cooking it for 1-2 minutes.

Step 4: Build the Sauce

Slowly pour in the milk, whisking to avoid lumps. Let the sauce simmer until it thickens. Stir in shredded mozzarella cheese and continue to whisk until it melts into a silky, creamy texture.

Step 5: Season and Combine

Season the sauce with salt and black pepper. Toss in the cooked fettuccine and mix until well coated. If the sauce is too thick, add a splash of reserved pasta water.

Step 6: Add the Chicken

Return the Cajun chicken to the pan and gently mix to combine everything. Let it heat through for another minute or two.

Step 7: Garnish and Serve

Sprinkle chopped parsley over the top before serving for a fresh, vibrant touch.

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How to Serve and Store This Creamy Cajun Chicken Fettuccine

Serve this pasta hot and fresh from the skillet for the best texture and flavor. A sprinkle of extra cheese or a few dashes of hot sauce can customize each plate to taste. If you’re hosting, consider presenting it in a large pasta bowl garnished with chopped parsley or grated parmesan.

To store leftovers, transfer the pasta to an airtight container and refrigerate for up to 3 days. When reheating, add a splash of milk or water to loosen the sauce and warm gently on the stove or in the microwave. Avoid overheating, which can cause the cheese sauce to separate.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread or Toasted Baguette

Perfect for soaking up any leftover cheese sauce on the plate.

Roasted Broccoli or Brussels Sprouts

Adds a healthy, earthy contrast to the rich pasta.

Caesar Salad

A classic pairing that offers crunch and tang.

Grilled Asparagus

A bright, green side that works well with Cajun spice.

Cornbread Muffins

If you’re leaning into Southern flavors, cornbread complements the Cajun vibe.

Fried Okra

Crispy, savory bites that pair perfectly with the creamy pasta.

Sparkling Lemon Water or Iced Tea

To cut through the richness and refresh your palate.

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Want More Pasta Dinner Ideas?

If you love this creamy Cajun chicken fettuccine, you’ll want to check out these other savory hits:

• Creamy Parmesan Italian Sausage Soup for cozy, comforting soup night.
• Creamy Crockpot Crack Chicken that melts in your mouth and feeds a crowd.
• White Cheddar Chicken Pasta for a sharper cheesy twist.
• Delicious Philly Cheese Steak Pasta when you’re craving meaty, cheesy pasta.
• Smoky BBQ Chicken Cheddar Pasta Skillet for a smoky-sweet pasta experience.

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Save this delicious idea to your favorite Pinterest board so it’s easy to find when you’re ready to whip it up again.

Tried it with a twist? Maybe a splash of bourbon or a drizzle of glaze? I’d love to hear how it turned out—drop your tips or questions in the comments below.

Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes on Pinterest. Your next favorite might be waiting there.

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