If comfort food had a passport, this creamy Cajun chicken rotini would be stamped with bold Southern flavors and creamy Italian indulgence. Imagine tender slices of perfectly seasoned chicken, seared to a golden crust, lounging on a bed of rotini swirled in luscious mozzarella Alfredo sauce. Every bite carries a whisper of Cajun spice, a creamy embrace of cheese, and the satisfying twirl of pasta that warms your soul.
This dish is a weeknight hero that tastes like a restaurant indulgence. It delivers that perfect balance of spice and creaminess, making it equally ideal for cozy family dinners or impressing guests without fuss. With every forkful, the creaminess of Alfredo meets the kick of Cajun seasoning, creating a culinary harmony that keeps you coming back for seconds.
What Makes Cajun Chicken Rotini Irresistible?
Cajun chicken rotini is all about bold flavors and creamy indulgence. The key is the perfect sear on the chicken and the richness of the mozzarella Alfredo sauce that clings to each rotini spiral. The combination of smoky paprika, garlic, and onion in Cajun seasoning ensures every bite is vibrant.


Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce
- Chicken Breasts: The heart of the dish, tender and protein-packed.
- Rotini Pasta: Spiral pasta that catches creamy Alfredo sauce in every twist.
- Cajun Seasoning: A robust blend of spices for heat and depth.
- Olive Oil & Butter: For searing and flavoring the chicken and sauce base.
- Garlic: Fresh cloves to infuse the sauce with savory richness.
- Heavy Cream: The foundation of that indulgent Alfredo texture.
- Mozzarella Cheese: Melts into the sauce for creamy, stretchy perfection.
- Parmesan Cheese: Adds a salty, nutty undertone to the Alfredo.
- Fresh Parsley: A bright, fresh finish for garnish and balance.
How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce
Step 1: Season and Sear the Chicken
Generously coat the chicken breasts with Cajun seasoning on both sides. In a hot skillet with olive oil and a touch of butter, sear the chicken until golden brown and fully cooked. Remove from the skillet and let it rest before slicing.
Step 2: Cook the Rotini Pasta
Bring a large pot of salted water to a boil. Cook the rotini until al dente according to package directions. Drain and set aside, reserving a cup of pasta water to help emulsify the sauce later.
Step 3: Prepare the Mozzarella Alfredo Sauce
In the same skillet used for the chicken, melt butter and sauté minced garlic until fragrant. Pour in heavy cream and let it gently simmer. Stir in shredded mozzarella and Parmesan cheese until the sauce becomes smooth and creamy. Add a splash of reserved pasta water if needed to reach the perfect silky consistency.
Step 4: Combine Pasta and Chicken
Add the cooked rotini to the skillet with the Alfredo sauce, tossing to coat every spiral. Slice the Cajun chicken and layer it over the pasta. Stir gently to combine, allowing the flavors to meld.
Step 5: Garnish and Serve
Sprinkle fresh parsley over the dish for a burst of color and freshness. Serve immediately, ensuring every plate gets a perfect balance of pasta, creamy sauce, and flavorful chicken.
Serving and Storing Creamy Cajun Chicken Rotini
This pasta dish is best enjoyed fresh when the sauce is creamy and silky. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove with a splash of cream or milk to bring back its luscious texture.
What to Serve With Creamy Cajun Chicken Rotini?
1. Garlic Bread
The ultimate companion to creamy pasta, perfect for soaking up any extra Alfredo sauce.
2. Caesar Salad
A crisp and refreshing salad with tangy dressing balances the richness of the pasta.
3. Roasted Broccoli or Asparagus
Adds a pop of color and a healthy, slightly crunchy side to your plate.
4. Caprese Salad
Fresh mozzarella, tomato, and basil make a vibrant, light pairing.
5. Creamy Coleslaw
Offers a cool and crunchy contrast to the warm, spicy pasta.
6. Parmesan Roasted Potatoes
For those who love a carb-on-carb moment, roasted potatoes with Parmesan work perfectly.
7. Sauteed Spinach with Garlic
Quick, healthy, and full of flavor—an excellent addition to the plate.
Want More Pasta Dinner Ideas?
If you love this Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce, here are a few more SavorQueen favorites you might enjoy:
- Cajun Chicken and Sausage Pasta Skillet – A bold, smoky pasta with extra depth from sausage.
- Garlic Butter Chicken with Rigatoni and Parmesan – A rich and satisfying chicken pasta classic.
- Smoky BBQ Chicken Cheddar Pasta Skillet – Sweet, smoky, and cheesy goodness in every bite.
- One-Pan Cajun Honey Butter Steak Pasta Wonder – Perfect for spice lovers and creamy pasta enthusiasts alike.
Save This Pin For Later
Save this delicious dinner idea to your favorite Pinterest board so you can make it whenever the craving hits!
Tried it with a twist? Maybe you added bell peppers or a splash of white wine? Share your tips or ask questions in the comments below—I’d love to hear from you!
Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes. Your next favorite comfort meal is waiting there!

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce
Equipment
- Large Skillet
- Pot for Pasta
- Tongs
Ingredients
- 2 chicken breasts
- 8 oz rotini pasta
- 2 tbsp Cajun seasoning
- 2 tbsp olive oil
- 2 tbsp butter
- 3 cloves garlic, minced
- 1 1/2 cups heavy cream
- 1 cup shredded mozzarella cheese
- 1/2 cup grated Parmesan cheese
- 2 tbsp chopped fresh parsley
Instructions
- Season chicken breasts with Cajun seasoning on both sides.
- Heat olive oil and 1 tbsp butter in a skillet; sear chicken until golden and fully cooked. Set aside.
- Cook rotini pasta in salted boiling water until al dente; reserve 1 cup pasta water and drain.
- In the same skillet, melt remaining butter and sauté garlic until fragrant.
- Stir in heavy cream; simmer gently. Add mozzarella and Parmesan until creamy and smooth.
- Add cooked rotini to sauce and toss to coat. Add pasta water as needed for creaminess.
- Slice chicken and place over pasta. Garnish with parsley and serve immediately.