Creamy, spicy, and absolutely satisfying, this Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta is the dinner dream you didn’t know you needed. Tender garlic-seasoned chicken bites are pan-seared to golden perfection and nestled into a rich Alfredo sauce with a Cajun twist. The sauce gets an extra boost of indulgence from melty cheese, wilted spinach, and artichoke hearts — turning an ordinary pasta night into a bold flavor experience.

The balance of spice and creaminess is what makes this dish unforgettable. The Cajun seasoning packs a smoky heat, while the Alfredo base tames it with buttery, cheesy goodness. Add to that a hearty pasta that clings to every drop of sauce, and you’ve got a comfort meal that comes together quickly and satisfies completely.

What Kind of Pasta Should I Use?

You can use any pasta that holds sauce well, such as rotini, penne, or cavatappi. The twists and ridges of these noodles are perfect for soaking up the creamy Cajun Alfredo. Cavatappi is a top choice because it adds a fun texture and an elegant presentation.

Ingredients for the Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta

Chicken breast – Cubed and seasoned, chicken breast offers lean protein and soaks in the Cajun flavor.
Garlic – Fresh minced garlic elevates both the chicken and the sauce with bold, aromatic notes.
Cajun seasoning – Adds smoky heat and Southern flair.
Butter & olive oil – For pan-searing the chicken and creating a rich base for the Alfredo sauce.
Heavy cream – Delivers the luxurious creaminess in the sauce.
Cream cheese – Gives the Alfredo its extra silky and tangy touch.
Parmesan cheese – Adds salty umami depth and classic Alfredo character.
Mozzarella cheese – For that stretchy, melty finish.
Spinach – Fresh baby spinach wilts beautifully into the sauce.
Artichoke hearts – Tender and tangy, they bring texture and balance.
Cooked pasta – Cavatappi or rotini work best to catch every bit of the sauce.
Red pepper flakes (optional) – A sprinkle for extra kick.

How To Make the Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta

Step 1: Sear the Chicken Bites

Season the chicken breast cubes generously with Cajun seasoning. Heat a large skillet over medium-high heat with butter and olive oil. Add the chicken and cook until golden brown and cooked through. Remove from the pan and set aside.

Step 2: Build the Alfredo Base

In the same skillet, add a little more butter and the minced garlic. Sauté until fragrant, about 30 seconds. Add the cream cheese and heavy cream. Stir until melted and smooth.

Step 3: Melt in the Cheese

Add the grated Parmesan and mozzarella cheeses to the skillet, stirring until fully melted into the sauce.

Step 4: Add the Veggies

Stir in the chopped spinach and artichoke hearts. Let them cook in the sauce until the spinach wilts and everything is well combined.

Step 5: Combine Pasta and Chicken

Toss the cooked pasta into the skillet and gently mix. Add the seared chicken bites back in. Stir everything together so the sauce coats evenly.

Step 6: Serve and Garnish

Plate it up hot, garnished with red pepper flakes and chopped parsley for color.

How to Serve and Store Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta

Serve this pasta piping hot straight from the skillet. The sauce will cling best when fresh. Store leftovers in an airtight container in the fridge for up to 3 days. To reheat, add a splash of milk or cream and warm gently on the stove or in the microwave to restore its creamy consistency.

What to Serve With Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta?

Cheesy Garlic Bread

The ultimate companion for wiping up every last drop of Alfredo sauce.

Simple Green Salad

A crisp salad with vinaigrette balances the richness beautifully.

Roasted Vegetables

Roasted zucchini, bell peppers, or asparagus add texture and freshness.

Cajun Shrimp Skewers

Double up on protein with spicy grilled shrimp for a coastal flair.

Sparkling Lemonade or Wine

Cleanses the palate and elevates your dinner experience.

Want More Pasta Dinner Ideas?

If you’re loving this comforting pasta dish, check out more cozy and creamy dinner options on Savor Queen:

Try this spicy and savory Cajun Chicken and Sausage Pasta Skillet for a meaty twist.
Dive into cheesy goodness with Cheesy Ranch Chicken and Broccoli Pasta Skillet.
Craving seafood? Our Creamy Crab Pasta Salad is a chilled option for warmer nights.
For a tangy touch, check out Garlic Butter Chicken with Rigatoni and Parmesan.
Need even more Cajun flavor? Don’t miss the Spicy Cajun Steak Mozzarella Alfredo Pasta.

Save This Pin For Later

Save this delicious idea to your favorite Pinterest board so it’s easy to find when you’re ready to whip it up again.

Tried it with a twist? Maybe a splash of bourbon or a drizzle of glaze? I’d love to hear how it turned out—drop your tips or questions in the comments below.

Need more inspiration? Explore my daily kitchen creations on Savor Queen Pinterest. Your next favorite might be waiting there.

Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta

Author: Julia Walton
Total Time: 40 minutes
Yield: 4 servings

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Description

Ready for a dinner that’ll have everyone begging for seconds? This Garlic Chicken Bites and Creamy Cajun Spinach Artichoke Alfredo Pasta is bold, creamy, and packed with flavor. It’s a satisfying skillet meal where pan-seared Cajun chicken bites meet a luscious Alfredo sauce, enriched with cream cheese, Parmesan, and a medley of spinach and artichokes. Perfect for those looking for easy dinner ideas, quick weeknight meals, or a cozy comfort food classic. If you’re after an easy recipe with big flavor, this dish checks all the boxes—from hearty to indulgent to weeknight-ready.