Julia Walton
Rich, indulgent, and bursting with Cajun flair, this Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce is the ultimate comfort meal for pasta lovers. Imagine tender spaghetti swirled in a luscious sauce made from Parmesan, mozzarella, and cream cheese, all coated with perfectly seasoned Cajun ground beef. Each bite delivers a harmonious blend of smoky spice and creamy decadence that feels like a hug in a bowl.
Perfect for cozy weeknights or when you want to impress guests with minimal effort, this recipe combines classic Italian comfort with a Southern twist. The Cajun spices bring a subtle heat that elevates the creaminess of the cheese sauce, while fresh herbs and juicy tomatoes add brightness to every forkful. This is a one-pan wonder that might just become your new family favorite.
What Makes Cajun Beef Spaghetti So Irresistible?
The magic lies in the combination of Cajun spices and a velvety three-cheese sauce. The beef is seared to lock in flavor, then simmered with aromatic garlic, onions, and a Cajun spice blend that infuses the entire dish. The creamy Parmesan sauce clings to each strand of spaghetti, creating a dish that’s indulgent without being heavy. Top it off with fresh parsley or thyme for a restaurant-quality finish at home.
Ingredients for Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce
- Ground beef – Provides a hearty, flavorful base for the sauce.
- Spaghetti – Classic long pasta that perfectly holds creamy sauces.
- Cajun seasoning – Adds smoky heat and depth to every bite.
- Garlic & onion – Build a rich, aromatic flavor foundation.
- Diced tomatoes – Introduce a hint of tang to balance the creaminess.
- Heavy cream – Creates a silky, indulgent sauce texture.
- Parmesan, mozzarella, and cream cheese – A trio of cheeses that melt into the ultimate creamy sauce.
- Fresh herbs (parsley or thyme) – Brighten the dish with fresh, aromatic notes.
- Olive oil & butter – Help sauté the beef and aromatics while enhancing richness.
- Salt & black pepper – Season to taste for the perfect flavor balance.
How To Make Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce
Step 1: Cook the Spaghetti
Bring a large pot of salted water to a boil and cook the spaghetti according to package instructions until al dente. Drain, toss lightly with a drizzle of olive oil, and set aside.
Step 2: Brown the Cajun Beef
Heat olive oil and butter in a large skillet over medium-high heat. Add the ground beef and sprinkle with Cajun seasoning. Cook until browned and slightly crispy at the edges, breaking it apart with a spatula. Remove the beef from the skillet and set aside.
Step 3: Sauté Aromatics and Build Flavor
In the same skillet, add diced onion and minced garlic. Sauté until fragrant and translucent. Deglaze with a splash of broth or water to lift the flavorful bits from the pan.
Step 4: Create the Creamy Three-Cheese Sauce
Reduce the heat to low. Stir in heavy cream, diced tomatoes, and cream cheese. Allow the cream cheese to melt completely, then add shredded mozzarella and grated Parmesan. Stir until the sauce is smooth and velvety.
Step 5: Combine Pasta and Sauce
Return the browned Cajun beef to the skillet, then toss in the cooked spaghetti. Stir well until every strand of pasta is coated in the luscious, cheesy sauce.
Step 6: Serve and Garnish
Plate the spaghetti and sprinkle with freshly chopped parsley or thyme. Optional: Add an extra pinch of Cajun seasoning or a sprinkle of Parmesan for a final touch of flavor.
Serving and Storing Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce
This indulgent pasta dish is best served hot right off the stove. The rich sauce will coat the spaghetti perfectly when freshly prepared. If you need to store leftovers, allow the pasta to cool completely before transferring it to an airtight container. It can be refrigerated for up to 3 days. Reheat gently on the stovetop with a splash of cream or milk to restore the silky texture.
Freezing is possible but may slightly alter the creaminess of the sauce. For best results, freeze only the sauce and prepare fresh pasta when ready to serve.
What to Serve with Cajun Beef Spaghetti?
1. Garlic Bread
The buttery, garlicky crunch of fresh garlic bread is a perfect partner for creamy pasta.
2. Caesar Salad
A crisp Caesar salad with tangy dressing balances the richness of the cheesy sauce.
3. Roasted Broccoli
The smoky, slightly charred flavor of roasted broccoli adds a healthy, earthy touch.
4. Caprese Salad
Fresh tomatoes, basil, and mozzarella provide a refreshing contrast to the warm Cajun flavors.
5. Sautéed Spinach
Lightly seasoned spinach adds a nutritious and simple side option.
6. Grilled Asparagus
The tender-crisp bite of grilled asparagus complements the hearty pasta beautifully.
7. Simple Dinner Rolls
Soft, warm rolls are ideal for mopping up every bit of that creamy three-cheese sauce.
Want More Pasta Ideas with a Cajun Twist?
If you love this Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce, you’ll also enjoy these other flavorful creations:
• Cajun Shrimp with Garlic Butter Sauce – A quick seafood dish with bold Southern flavors.
• Spaghetti Spinach with Sun-Dried Tomato Cream Sauce – A lighter, veggie-packed creamy pasta.
• Classic Spaghetti Carbonara – Traditional Italian comfort with a creamy, savory twist.
• Ultimate One-Pan Creamy Honey Butter Steak Pasta – Hearty, rich, and perfect for steak lovers.
• Garlic Butter Steak Parmesan Rigatoni – Indulgent, garlicky, and perfect for weeknight dinners.
Save This Pin For Later
Save this delicious pasta to your favorite Pinterest board so you can make it whenever the craving strikes.
Tried it with a twist? Maybe you added a splash of hot sauce or sprinkled extra Parmesan on top? I’d love to hear how yours turned out—share your tips and variations!
Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes. Your next favorite comfort meal might be waiting there!
Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce
Equipment
- Large Skillet
- Large pot
- Spatula
- Colander
Ingredients
- 1 lb ground beef
- 12 oz spaghetti
- 2 tbsp Cajun seasoning
- 1 medium onion, diced
- 3 cloves garlic, minced
- 1 cup diced tomatoes
- 1 cup heavy cream
- 4 oz cream cheese
- 1 cup shredded mozzarella cheese
- 0.5 cup grated Parmesan cheese
- 2 tbsp olive oil
- 1 tbsp butter
- 2 tbsp fresh parsley or thyme, chopped
- Salt and black pepper to taste
Instructions
- Cook spaghetti in salted boiling water until al dente. Drain and toss with olive oil.
- Heat olive oil and butter in a skillet. Cook beef with Cajun seasoning until browned. Remove and set aside.
- Sauté onion and garlic. Deglaze if needed.
- Add heavy cream, tomatoes, and cream cheese. Stir until smooth. Add mozzarella and Parmesan to make a creamy sauce.
- Return beef and add spaghetti. Toss until coated.
- Garnish with parsley and serve hot.