This Cheesy Garlic Cajun Chicken Bowtie Pasta is a flavor-packed comfort dish that combines tender bowtie pasta with creamy Alfredo sauce and smoky-spicy Cajun chicken. The pasta’s ridged folds hold onto every drop of sauce, delivering a satisfying bite every time. Juicy, seared chicken adds protein and richness, while fresh parsley and Parmesan brighten each serving.

The Cajun spices add warmth without overpowering the creamy, garlicky sauce. It’s a perfect weeknight dinner that feels special enough for guests, pairing bold Southern flavors with Italian-inspired indulgence.

What Kind of Cajun Seasoning Should I Use?

Choose a Cajun seasoning with a balanced mix of paprika, garlic powder, onion powder, oregano, thyme, and cayenne. Look for blends that aren’t overly salty so you can control the seasoning. For extra heat, add more cayenne or a sprinkle of red pepper flakes.

Ingredients for Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Bowtie pasta (farfalle): Holds sauce well in each fold.
Chicken breasts: Lean and tender, perfect for Cajun seasoning.
Cajun seasoning: Smoky, bold, and aromatic.
Garlic cloves: Freshly minced for full flavor.
Heavy cream: Base of the rich Alfredo sauce.
Parmesan cheese: Adds nutty, salty depth.
Butter: Enhances flavor and helps cook the garlic.
Olive oil: For a golden sear on the chicken.
Fresh parsley: Adds brightness and color.
Salt & black pepper: Balances the flavors.

How To Make the Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add bowtie pasta and cook until al dente according to package directions. Drain, reserving a cup of pasta water.

Step 2: Season and Sear the Chicken

Pat chicken breasts dry and coat with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat and sear chicken for 5–6 minutes per side until golden and cooked through. Remove and let rest before slicing.

Step 3: Make the Garlic Alfredo Sauce

In the same skillet, reduce heat to medium. Add butter and minced garlic, sautéing until fragrant. Stir in heavy cream, then gradually whisk in Parmesan until smooth.

Step 4: Combine and Serve

Add cooked pasta to the sauce, tossing to coat. Thin with reserved pasta water if needed. Top with sliced Cajun chicken, fresh parsley, and extra Parmesan.

Serving and Storing Cheesy Garlic Cajun Chicken Bowtie Pasta

Serve immediately while hot, garnished with parsley and Parmesan. For storage, let it cool and refrigerate in an airtight container for up to 3 days. Reheat gently on the stove with a splash of cream or milk to revive the sauce.

What to Serve With Cheesy Garlic Cajun Chicken Bowtie Pasta?

Garlic Bread

Perfect for soaking up the creamy Alfredo sauce.

Roasted Vegetables

Adds balance and a pop of color to your plate.

Caesar Salad

Crisp, tangy, and refreshing alongside the rich pasta.

Grilled Asparagus

Light and earthy to complement the bold flavors.

Caprese Salad

Fresh mozzarella, tomato, and basil for a cool contrast.

Sauteed Green Beans

Simple, buttery, and vibrant.

Chilled White Wine

A crisp Sauvignon Blanc or Chardonnay pairs beautifully.

Want More Pasta Ideas?

If you love this Cajun chicken pasta, try these other favorites from my kitchen:

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Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Craving a bold, creamy pasta that tastes like a restaurant favorite yet fits your weeknight schedule? Cheesy Garlic Cajun Chicken Bowtie Pasta brings juicy, spice‑rubbed chicken together with silky Alfredo that hugs every bowtie. It’s a quick dinner with big flavor, perfect for busy nights or casual company. Think easy recipe meets comfort food ideas: creamy pasta, Cajun heat, and plenty of Parmesan. Great for dinner ideas, family meals, and “what’s for supper?” moments—fast, cozy, and totally craveable.

Print Recipe Pin Recipe

Prep Time 15

Cook Time 25

Total Time 40

Course Dinner

Cuisine American, Cajun

Servings servings

Calories 720 kcal

Equipment

Large pot
Large Skillet
Tongs
Chef’s knife

Ingredients

12 oz bowtie pasta
1.5 lb boneless skinless chicken breasts
2 tbsp Cajun seasoning divided
1 tsp fine sea salt
0.5 tsp black pepper
2 tbsp olive oil
3 tbsp unsalted butter
4 clove garlic, minced
2 cup heavy cream
1 cup freshly grated Parmesan cheese plus more to serve
0.5 cup reserved pasta water as needed
2 tbsp chopped fresh parsley
0.25 tsp red pepper flakes optional
1 tbsp fresh lemon juice optional

Instructions

Bring a large pot of salted water to a boil. Cook bowtie pasta until al dente; reserve 1/2 cup pasta water and drain.
Season chicken with 1 1/2 tbsp Cajun seasoning, salt, and pepper. Heat olive oil in a large skillet over medium-high; sear 5–6 minutes per side until cooked through. Rest, then slice.
Reduce heat to medium. Add butter and garlic; cook 30–60 seconds. Stir in heavy cream and remaining Cajun seasoning; simmer 2–3 minutes. Whisk in Parmesan until smooth.
Add drained pasta; toss to coat, loosening with reserved pasta water as needed. Stir in lemon juice if using.
Top with sliced chicken, parsley, and red pepper flakes. Serve hot with extra Parmesan.

Notes

For extra cheesy richness, add 1/2 cup shredded mozzarella when tossing the pasta. When reheating, add a splash of milk or cream and warm gently over low heat.

Nutrition

Calories: 720kcalCarbohydrates: 55gProtein: 42gFat: 38gSaturated Fat: 19gCholesterol: 165mgSodium: 980mgFiber: 3gSugar: 3gVitamin A: 900IUVitamin C: 6mgCalcium: 380mgIron: 2.5mg

Keyword alfredo, Cajun chicken pasta, easy pasta, quick dinner, weeknight meals

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