Julia Walton
Nothing says comfort quite like a plate of creamy, cheesy spaghetti loaded with hearty Cajun-seasoned beef. This dish brings the warmth of Southern spices and the indulgence of Italian comfort food together in one skillet. Each forkful is packed with a rich, savory meat sauce, tender spaghetti, and a luscious blend of melted cheeses that cling to every strand.
Whether you’re cooking for a weeknight family dinner or hosting friends, this recipe is a guaranteed crowd-pleaser. The Cajun seasoning infuses every bite with a gentle kick, while the creamy three-cheese Parmesan sauce adds a decadent finish that will make you want seconds. It’s hearty, flavorful, and irresistibly cozy—the ultimate fusion pasta for your table.
What Makes This Cajun Spaghetti Special?
If you’re wondering why this isn’t just another spaghetti night, the answer is in the details. The Cajun seasoning gives the beef a smoky, peppery edge that elevates the flavor profile beyond a classic marinara or bolognese. Adding the three-cheese Parmesan sauce transforms it into a creamy, indulgent pasta that balances spice with velvety richness.
This combination is perfect for anyone who craves bold flavors without spending hours in the kitchen. It’s a one-pan wonder that delivers restaurant-quality results right at home.
Ingredients for Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce
- Ground Beef – Adds heartiness and absorbs all the Cajun spices beautifully.
- Spaghetti – The perfect pasta to hold the sauce and cheese in every bite.
- Cajun Seasoning – Brings a smoky, slightly spicy kick that defines this dish.
- Garlic and Onion – Provide aromatic depth and a savory foundation for the sauce.
- Tomato Sauce – Gives the beef base a rich, tangy body that pairs with the cheese.
- Heavy Cream – Essential for creating a silky, creamy sauce texture.
- Parmesan, Mozzarella, and Cheddar Cheeses – A trio of melty cheeses that make the sauce luxurious.
- Fresh Parsley – Adds color and a touch of freshness to balance the richness.
How To Make Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce
Step 1: Cook the Pasta
Bring a large pot of salted water to a boil. Cook the spaghetti according to the package instructions until al dente. Drain and set aside, tossing lightly with olive oil to prevent sticking.
Step 2: Brown the Beef
In a deep skillet or Dutch oven, cook the ground beef over medium-high heat until browned and crumbly. Drain excess fat if necessary. Add the diced onions and minced garlic, sautéing until fragrant.
Step 3: Season and Simmer
Stir in the Cajun seasoning, coating the beef evenly. Add the tomato sauce and let it simmer for 5–7 minutes to absorb the flavors. This is the base that will carry all the richness of the final sauce.
Step 4: Make the Creamy Three-Cheese Sauce
Lower the heat and pour in the heavy cream, stirring gently. Slowly add the Parmesan, Mozzarella, and Cheddar cheeses, mixing until melted into a smooth, creamy sauce that hugs the beef.
Step 5: Combine Pasta and Sauce
Toss the drained spaghetti into the skillet, ensuring every strand is coated with the cheesy Cajun sauce. Cook for an additional 2–3 minutes so the pasta absorbs the flavors.
Step 6: Garnish and Serve
Top with chopped parsley and extra Parmesan if desired. Serve hot, straight from the pan for that irresistible, comforting aroma.
Serving and Storing Creamy Cajun Beef Spaghetti
This pasta is best served hot, straight from the skillet when the cheese is gooey and the sauce is at peak creaminess. If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. To reheat, add a splash of milk or cream in a skillet over low heat to restore the creamy texture.
What to Serve With Creamy Cajun Beef Spaghetti?
1. Garlic Bread
Buttery, golden garlic bread makes the perfect companion to soak up the creamy sauce.
2. Caesar Salad
A crisp, tangy Caesar salad adds freshness and balances the richness of the pasta.
3. Roasted Vegetables
Oven-roasted broccoli, bell peppers, or zucchini add a wholesome and colorful touch.
4. Caprese Salad
Tomatoes, mozzarella, and basil with a drizzle of balsamic reduce the heaviness of the meal.
5. Cornbread Muffins
A slightly sweet and crumbly cornbread pairs wonderfully with Cajun flavors.
6. Sautéed Green Beans
Garlicky green beans bring a crunchy, savory side that’s quick to make.
7. Antipasto Platter
A mix of olives, cured meats, and cheese can serve as a simple appetizer before the main course.
Want More Pasta Ideas with a Cajun Twist?
If this creamy Cajun beef spaghetti has your tastebuds tingling, try these other flavorful dishes from SavorQueen:
- Cajun Shrimp with Garlic Butter Sauce
- Spaghetti Spinach with Sun-Dried Tomato Cream Sauce
- Garlic Butter Steak Parmesan Rigatoni
- Ultimate One-Pan Creamy Honey Butter Steak Pasta
- One-Pot Creamy Cajun BBQ Steak Sausage Penne
Save This Pin For Later
Save this delicious idea to your favorite Pinterest board so you can find it easily next time you’re craving a rich and spicy pasta night.
Tried a twist? Maybe you added mushrooms, used smoked sausage, or even added a little crushed red pepper for extra heat? Share your tips and kitchen wins in the comments below.
Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes on Pinterest. Your next favorite might be waiting there!
Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce
Equipment
- Large pot
- Skillet or Dutch oven
- Wooden spoon
- Colander
Ingredients
- 1 lb ground beef
- 12 oz spaghetti
- 2 tbsp Cajun seasoning
- 1 small onion, diced
- 3 cloves garlic, minced
- 2 cups tomato sauce
- 1 cup heavy cream
- 1 cup Parmesan cheese, shredded
- 1 cup Mozzarella cheese, shredded
- 1 cup Cheddar cheese, shredded
- 2 tbsp fresh parsley, chopped
Instructions
- Cook spaghetti in salted boiling water until al dente, drain, and set aside.
- In a skillet, brown the ground beef. Drain excess fat. Add onions and garlic; sauté until fragrant.
- Stir in Cajun seasoning and tomato sauce; simmer 5–7 minutes.
- Reduce heat, add heavy cream, and slowly mix in Parmesan, Mozzarella, and Cheddar until creamy.
- Toss spaghetti with the sauce and cook 2–3 more minutes to absorb flavors.
- Garnish with parsley and serve hot.