Rich, smoky, and irresistibly creamy, this Cajun chicken bowtie pasta is the perfect comfort dish for weeknights or entertaining. Tender grilled chicken coated in a bold Cajun seasoning sits on a bed of buttery bowtie pasta tossed in a luscious garlic cheese sauce. Every bite delivers that satisfying balance of spice, creaminess, and cheesy goodness.
This is the kind of meal that transforms your kitchen into a cozy bistro. The velvety sauce clings to every curve of the pasta, while the juicy chicken provides a savory, smoky bite. Plus, it’s a one-pan wonder that feels fancy but comes together with simple pantry ingredients.
What Makes This Cajun Pasta So Delicious?
The secret is the combination of smoky Cajun spices with a rich, garlicky cheese sauce that coats every piece of bowtie pasta. Using a skillet to sear the chicken first infuses the pasta with layers of flavor, and finishing with a generous sprinkle of cheese makes it melt-in-your-mouth irresistible.


Ingredients for Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce
- Chicken breast – Lean protein that soaks up the Cajun spice beautifully.
- Bowtie (farfalle) pasta – Its shape holds the creamy sauce perfectly.
- Cajun seasoning – Provides that smoky heat and signature Southern flavor.
- Garlic cloves – Fresh garlic deepens the savory notes of the sauce.
- Heavy cream – Creates a luxurious, rich base for the cheese sauce.
- Shredded cheddar and mozzarella – Melt into the sauce for ultimate cheesiness.
- Olive oil & butter – Used for sautéing and adding richness.
- Fresh parsley – For a pop of color and fresh herbal finish.
How To Make Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce
Step 1: Prepare the Chicken
Pat chicken breasts dry and coat them generously with Cajun seasoning. Heat olive oil in a large skillet over medium-high heat, sear the chicken for 4-5 minutes per side until golden and cooked through. Remove from the skillet and let it rest before slicing.
Step 2: Cook the Bowtie Pasta
Bring a large pot of salted water to a boil and cook the bowtie pasta until al dente. Reserve 1 cup of pasta water, then drain and set aside.
Step 3: Make the Garlic Cheese Sauce
In the same skillet used for chicken, melt butter and sauté minced garlic until fragrant. Stir in heavy cream, followed by the shredded cheeses, stirring until smooth. Add a splash of pasta water if needed for a silky consistency.
Step 4: Combine and Serve
Add the cooked pasta to the sauce, tossing until fully coated. Top with sliced Cajun chicken and sprinkle with fresh parsley. Serve hot with extra cheese if desired.
Serving and Storing Creamy Cajun Chicken Bowtie Pasta
This pasta is best enjoyed fresh off the stove, while the cheese sauce is warm and creamy. Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stove with a splash of milk or cream to bring back the silky texture.
What to Serve with Creamy Cajun Chicken Bowtie Pasta?
Garlic Bread
Warm, buttery garlic bread is perfect for soaking up any leftover sauce.
Simple Green Salad
A crisp salad with a light vinaigrette balances the richness of the pasta.
Roasted Vegetables
Try roasted broccoli, asparagus, or bell peppers for a healthy side.
Corn on the Cob
Sweet corn pairs beautifully with the smoky Cajun flavors.
Classic Caesar Salad
The tangy dressing and crunchy croutons are a refreshing contrast.
Lemon Wedges
A squeeze of lemon over the pasta can brighten the flavors.
Sparkling Water or Iced Tea
Keeps the meal refreshing without overpowering the spices.
Want More Creamy Pasta Dinner Ideas?
If you love this Creamy Cajun Chicken Bowtie Pasta, check out these other comforting dishes:
- Creamy Velveeta Beef Bowtie Pasta
- Spicy Cajun Steak Mozzarella Alfredo Pasta
- Garlic Butter Chicken with Rigatoni and Parmesan
- One Pan Cajun Honey Butter Steak Pasta Wonder
- Cajun Chicken and Sausage Pasta Skillet
Save This Pin For Later
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Tried it with a twist? Maybe added sun-dried tomatoes or a sprinkle of smoked paprika? Share your version in the comments!
Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes. Your next favorite might be waiting there.

Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce
Equipment
- Large Skillet
- Pot for Pasta
- Tongs
- Cutting Board
Ingredients
Ingredients
- 2 large chicken breasts
- 8 oz bowtie pasta
- 1 1/2 tbsp Cajun seasoning
- 3 cloves garlic, minced
- 1 tbsp olive oil
- 2 tbsp butter
- 1 cup heavy cream
- 1 cup shredded cheddar cheese
- 1/2 cup shredded mozzarella cheese
- 1 tbsp fresh parsley, chopped
Instructions
- Pat chicken dry and rub with Cajun seasoning. Heat olive oil in a skillet and cook chicken for 4-5 minutes per side until golden and fully cooked. Remove and rest, then slice.
- Boil bowtie pasta in salted water until al dente. Reserve 1 cup of pasta water, drain, and set aside.
- In the same skillet, melt butter and sauté garlic until fragrant. Pour in heavy cream, then stir in cheddar and mozzarella until smooth. Add pasta water if needed for a creamy consistency.
- Toss pasta in sauce, top with sliced chicken, and garnish with parsley. Serve hot.