If you crave a dish that blends creamy comfort with bold spice, this Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites delivers on every level. The rich, melt-in-your-mouth cheese sauce clings to perfectly cooked penne pasta, while the Cajun-seasoned beef bites provide a savory, peppery contrast that takes it to a whole new level.

This is the kind of meal that doesn’t just satisfy hunger—it makes a statement. Whether you’re feeding a hungry crowd or just treating yourself on a cozy night in, this plate brings both the wow factor and the soul-soothing satisfaction of a home-cooked favorite.

What Kind of Pasta Should I Use for Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites?

Penne pasta is ideal for this recipe thanks to its tube shape, which holds onto that creamy Velveeta cheese sauce like a dream. It’s sturdy, satisfying, and doesn’t get lost under the boldness of the Cajun beef. If you don’t have penne on hand, rigatoni or ziti will work just as well.

Ingredients for the Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

Penne Pasta
Essential for structure and heartiness, penne pasta absorbs the cheese sauce and adds a satisfying bite.

Velveeta Cheese (Original)
This is the soul of the sauce. It melts into a silky base that’s rich and velvety smooth.

Four-Cheese Blend (Mozzarella, Parmesan, Cheddar, Provolone)
This quartet adds depth and a more complex cheesy flavor that balances Velveeta’s creaminess.

Heavy Cream
Lends luxurious texture and helps melt and marry the cheeses into a perfect sauce.

Butter
Adds richness and keeps the sauce from getting too thick or sticky.

Garlic Powder & Onion Powder
Both boost the savoriness of the sauce without overwhelming the cheese.

Cajun Seasoning
This is key for flavoring the beef. It brings heat, smokiness, and that signature Southern kick.

Beef Sirloin (cut into bite-sized cubes)
Perfectly tender and juicy when seared—it stands up to the cheese and spices.

Olive Oil
Used for searing the beef to a beautiful golden-brown crust.

Salt & Pepper
A simple but crucial step in seasoning everything to perfection.

Parsley (optional)
Adds a touch of color and freshness to finish the dish.

How To Make the Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

Step 1: Boil the Pasta

Cook penne pasta in salted boiling water according to the package directions. Drain and set aside.

Step 2: Sear the Cajun Beef Bites

Toss the beef cubes in Cajun seasoning, salt, and pepper. In a skillet over medium-high heat, add olive oil and sear the beef until browned and cooked to your liking. Remove from skillet and set aside.

Step 3: Make the Velveeta Cheese Sauce

In the same skillet, lower the heat and melt butter. Add heavy cream, garlic powder, and onion powder. Stir in the Velveeta cubes and cook until melted and smooth.

Step 4: Add the Four-Cheese Blend

Once the Velveeta is melted, stir in the shredded four-cheese blend. Keep stirring until fully incorporated and creamy.

Step 5: Combine Pasta and Cheese Sauce

Add the drained pasta to the skillet and gently fold it into the cheese sauce until well coated.

Step 6: Finish with Cajun Beef

Top the cheesy pasta with the seared Cajun beef bites. Garnish with chopped parsley if desired.

Serving and Storing Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

Serve this dish hot and fresh out of the skillet for the best experience. The cheese sauce is at its silkiest right after cooking. If you’re storing leftovers, keep them in an airtight container in the refrigerator for up to 3 days. Reheat on the stove with a splash of cream or milk to bring back the creamy texture.

What to Serve With Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites?

Garlic Bread

Crunchy, buttery garlic bread is perfect for scooping up extra cheese sauce.

Roasted Broccoli

Roasted with olive oil and sea salt, this veggie adds freshness and a bit of crunch.

Southern-Style Green Beans

Slow-cooked green beans with a touch of bacon pair wonderfully with Cajun beef.

Caesar Salad

A crisp Caesar salad lightens up the meal and adds tangy contrast.

Corn on the Cob

Sweet corn offsets the spice and richness of the beef and cheese.

Fried Okra

If you’re feeling extra Southern, crispy fried okra is a nostalgic side that fits perfectly.

Jalapeño Cornbread

Add more kick and texture with this spicy, cheesy cornbread on the side.

Want More Pasta Ideas with a Southern Twist?

If you love this penne with Velveeta and Cajun beef, you’ll want to explore these other bold, cheesy, and satisfying dinners:

Creamy Velveeta Beef Bowtie Pasta for another take on creamy comfort.
One-Pot Creamy Cajun BBQ Steak Sausage Penne for those craving deep Southern spice.
Garlic Butter Steak Parmesan Rigatoni if you want steak and pasta to shine together.
Smoky BBQ Chicken Cheddar Pasta Skillet for a smoky-sweet balance.
Cheesy Ranch Chicken Garlic Butter Fettuccine for indulgent weeknight comfort.

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Save this delicious idea to your favorite Pinterest board so it’s easy to find when you’re ready to whip it up again.

Tried it with a twist? Maybe with spicy sausage instead or added veggies? I’d love to hear how it turned out—drop your tips or questions in the comments below.

Need more inspiration? Explore my daily kitchen creations on SavorQueen Recipes on Pinterest. Your next favorite might be waiting there.

Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites

This Penne with Creamy Velveeta Four-Cheese and Cajun Beef Bites recipe is pure comfort food with a kick. Tender penne pasta is drenched in a velvety cheese sauce made from classic Velveeta and a four-cheese blend, creating layers of creamy richness. On top of that, Cajun-spiced beef bites bring heat, smokiness, and a juicy bite that balances the smooth sauce. Perfect for easy dinner nights, cozy weekend meals, or when you just need a satisfying food idea. It’s one of those quick dinner ideas that feels gourmet but comes together effortlessly, ticking the boxes for easy recipes and comfort food cravings.

Print Recipe Pin Recipe

Prep Time 15

Cook Time 20

Total Time 35

Course Dinner

Cuisine Southern

Servings servings

Calories 785 kcal

Equipment

Large pot
skillet
Wooden spoon

Ingredients

1 lb penne pasta
1 tbsp olive oil
1 lb beef sirloin, cut into bite-sized cubes
1.5 tbsp Cajun seasoning
0.5 tsp salt
0.5 tsp black pepper
2 tbsp butter
1 cup heavy cream
1 tsp garlic powder
1 tsp onion powder
8 oz Velveeta cheese, cubed
1 cup shredded mozzarella
0.5 cup shredded cheddar
0.5 cup shredded Parmesan
0.5 cup shredded provolone
1 tbsp chopped parsley (optional)

Instructions

Boil pasta in salted water until al dente. Drain and set aside.
Season beef with Cajun seasoning, salt, and pepper.
Heat olive oil in skillet over medium-high. Sear beef until browned and cooked through. Set aside.
In the same skillet, melt butter. Add cream, garlic powder, and onion powder.
Stir in Velveeta until smooth.
Add shredded cheeses, stirring until creamy and combined.
Mix pasta into cheese sauce until fully coated.
Top with cooked Cajun beef. Garnish with parsley if desired. Serve hot.

Notes

For extra heat, use spicy Cajun seasoning or add red pepper flakes.
Reheat leftovers gently with a splash of cream to maintain the sauce’s texture.

Nutrition

Calories: 785kcalCarbohydrates: 58gProtein: 40gFat: 45gSaturated Fat: 25gCholesterol: 130mgSodium: 890mgFiber: 3gSugar: 4gVitamin A: 900IUVitamin C: 2mgCalcium: 480mgIron: 4mg

Keyword comfort food, dinner ideas, easy recipe, pasta recipes, Velveeta recipes

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